US 7,597,897 B2 · Medicinal compositions and method for the preparation thereof

Abstract

Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.

Claims35

Dependent claims

A method for the manufacture of a medicinal composition comprising:

(a) Providing a biocompatible polymer of the general formula
—[O—R1—C(O)]n—
wherein:
“R1” is a linear, branched, or cyclic organic group,
“n” is at least three,
(b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride;
(c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water;
(d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid;
and
(e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.

7 more elements

A method for the manufacture of a medicinal composition comprising:

(a) Providing a biocompatible polymer comprising oligolactic acid;
(b) Acylating the biocompatible polymer to provide acyl oligolactic acid and a mixed anhydride;
(c) Reacting the mixed anhydride with a tertiary alcohol in the absence of water to provide an ester that can be chemically converted to an acylated acid comprising acyl oligolactic acid, the alcohol having at least one hydrogen in the alpha position;
(d) Converting the ester to acyl oligolactic acid;
and
(e) Combining the acyl oligolactic acid with a drug to provide the medicinal composition.

3 more elements

A method for the manufacture of a medicinal composition comprising:

(a) Providing a biocompatible polymer comprising oligolactic acid;
(b) Acetylating the biocompatible polymer to provide acetyl oligolactic acid and a mixed anhydride of acetyl oligolactic acid and acetic acid;
(c) Reacting the mixed anhydride with a tertiary alcohol to provide an ester that can be chemically converted to an acid comprising acetyl oligolactic acid in the absence of water;
(d) Converting the ester to acetyl oligolactic acid;
and
(e) Combining the acetyl oligolactic acid with a drug to provide the medicinal composition.

3 more elements

Dependencies are inferred from the claim text.

Medicinal compositions and method for the preparation thereof

Life of this patent

Medicinal compositions and method for the preparation thereof

Life of this patent

Abstract

Claims35