Human monoclonal antibody specific lipopolysaccharides (LPS) of serotype IATS 06 of Pseudomonas aeruginosa
AssigneeKenta Biotech AG
InventorsAlois B. Lang, Michael P. Horn, Martin A. Imboden
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Abstract
The present application relates to a human monoclonal antibody specific for the serotype IATS 06 of P. aeruginosa, a hybridoma producing it, nucleic acids encoding it, and host cells transfected therewith. Further, the present invention relates to methods for producing said monoclonal antibody. In addition, the present invention relates to pharmaceutical compositions comprising at least one antibody or at least one nucleic acid encoding said antibody.
Claims21
A human monoclonal antibody specific for LPS of the Pseudomonas aeruginosa LPS serotype IATS 06, wherein the variable region of the light chain of said antibody comprises the amino acid sequence of SEQ ID NO:7 and the variable region of the heavy chain of said antibody comprises the amino acid sequence of SEQ ID NO:8, or a variant of said antibody capable of binding said LPS, wherein the amino acid sequence of the variable region of the light chain of said variant of said antibody is at least 85% homologous to SEQ ID NO:7 and the amino acid sequence of the variable region of the heavy chain of said variant of said antibody is at least 85% homologous to SEQ ID NO:8.
An isolated nucleic acid encoding a light chain of a human monoclonal antibody, wherein said nucleic acid encodes a polypeptide comprising the sequence set forth in SEQ ID NO:7.
An isolated nucleic acid encoding a heavy chain of a human monoclonal antibody, wherein said nucleic acid encodes a polypeptide comprising the sequence set forth in SEQ ID NO:8.
A vector comprising at least one nucleic acid selected from the group consisting of:
- a) an isolated nucleic acid encoding a light chain of a human monoclonal antibody, wherein said nucleic acid encodes a polypeptide comprising the sequence set forth in SEQ ID NO:7;
- and, b) an isolated nucleic acid encoding a heavy chain of a human monoclonal antibody, wherein said nucleic acid encodes a polypeptide comprising the sequence set forth in SEQ ID NO:8.
A host cell comprising an isolated nucleic acid, wherein said nucleic acid is selected from the group consisting of:
- a) an isolated nucleic acid encoding a light chain of a human monoclonal antibody, wherein said nucleic acid encodes a polypeptide comprising the sequence set forth in SEQ ID NO:7;
- and, b) an isolated nucleic acid encoding a heavy chain of a human monoclonal antibody, wherein said nucleic acid encodes a polypeptide comprising the sequence set forth in SEQ ID NO:8.
Dependencies are inferred from the claim text.