Back to results
US 7,597,886 B2Granted
Tumor necrosis factor-gamma
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
Estimating the term…
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
A method of treating an inflammatory disease or disorder comprising administering to an animal in which such treatment is desired an antibody or fragment thereof that specifically binds and antagonizes a TNF-gamma-beta protein comprising SEQ ID NO:20 in an amount effective to treat or ameliorate an inflammatory disease or disorder,
A method of treating inflammation comprising administering to an animal in which such treatment is desired an antibody or fragment thereof that specifically binds and antagonizes a TNF-gamma-beta protein comprising SEQ ID NO:20 in an amount effective to treat or ameliorate an inflammation associated with tissue-specific inflammatory disorders,
A method of treating an autoimmune disease or disorder comprising administering to an animal in which such treatment is desired an antibody or fragment thereof that specifically binds and antagonizes a TNF-gamma-beta protein comprising SEQ ID NO:20 in an amount effective to treat or ameliorate an inflammation associated with Crohn's disease.
Dependencies are inferred from the claim text.