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US 7,597,882 B2Granted
Protein crosslinkers, crosslinking methods and applications thereof
AssigneeIncept, LLC
InventorsChandrashekhar P. Pathak, Amarpreet S. Sawhney, James H. Dreher
Life of this patent
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Abstract
Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum.
Claims12
A low molecular weight precursor comprising:
- a biocompatible liquid crosslinker with a molecular weight of no more than about 2000 Daltons that comprises at least three activated acid functional groups that are strong electrophiles selected from the group consisting of succinimide, succinimide ester, N-hydroxysuccinimide ester and maleimide, wherein the crosslinker forms a melt at less than about 50° C., wherein the strong electrophiles are not reactable by a Michaels-type reaction.
Dependencies are inferred from the claim text.