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US 7,597,878 B2Granted
Optical fluorescent imaging
AssigneeLI-COR, Inc.
InventorsJoy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Abstract
Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
Claims38
A compound of the formula:
- wherein Cat+ is a cation;
- r is an integer equal to 1, 2 or 3;
- X and Y are each independently O, S, Se, or (CH3)2C;
- and
- R8 and R13 are each independently alkyl, L—R25 or L—B;
- wherein at least one of R8 and R13 is L—B;
- R25 is a member selected from the group consisting of optionally substituted alkyl, hydroxyl, thioacetyl and sulfanato;
- L is a linker;
- B is a ligand;
- n is 0, 1, 2 or 3;
- R11 and R12 are each independently F, H, sulfonato, or together with the atoms to which they are bonded form an aromatic ring;
- and
- R16 and R17 are each independently H, sulfonato, or together with the atoms to which they are bonded form an aromatic ring.
10 more elements
Dependencies are inferred from the claim text.