High performance liquid chromatography sample introduction optimized with bubble detection

A device for identifying a condition in a fluid system and initiating a response, the fluid system comprising a fluid conduit having an input end and an output end connected to a fluid movement means for moving an aliquot of fluid, said fluid movement means responsive to a fluid movement command signal, said device comprising:

• a sensor for placement in communication with a fluid in said fluid system and disposed between said fluid movement means and said output end, said sensor outputting a first signal in response to said fluid in a gaseous state and a second signal in response to said fluid in a liquid state;
• and
• a control means for receiving said first signal and said second signal, for issuing at least one command signal in response to the condition, for sending at least one command signal for initiating a response based on said received signals, and for issuing at least one fluid movement command signal for causing said fluid movement means to draw fluid in through said input end at a rate,
• wherein said sensor and control means are placed in said fluid system, and
• wherein said control means issues at least one fluid movement command signal for increasing said rate while receiving said second signal and at least one fluid movement command signal for decreasing said rate while receiving said first signal, wherein said fluid is moved at an optimum rate that prevents vaporization of said fluid.