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US 7,595,397 B2Granted
Compounds which modulate the CB2 receptor
AssigneeBoehringer Ingelheim International GmbH
InventorsRenee Zindell, Doris Riether, David S. Thomson, Eugene Richard Hickey, Innocent Mushi, Monika Ermann
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Abstract
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula wherein, R1, R2, A, Y, X, Ar1 and Ar2 have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.
Claims4
A compound of a formula:
- or the pharmaceutically acceptable salts thereof wherein,
- R1 is phenyl or benzyl;
- R2 is hydrogen or C1-C6 alkyl;
- A is a group of the formula —(CH2)n—, wherein n is 2;
- Y is O;
- or,
- X is a methylene group;
- Ar1 is 1,4-phenylene;
- and,
- Ar2 is phenyl, which is optionally mono-substituted with chloro, cyano, trifluoromethyl, methoxy or ethoxy or disubstituted with chloro,
- or a salt thereof.
8 more elements
Dependencies are inferred from the claim text.