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US 7,595,060 B2Granted
Yeast-antigen compositions methods of making the same
AssigneesGlobeImmune, Inc., The Regents of the University of Colorado
InventorsRichard C. Duke, Donald Bellgrau, Alex Franzusoff, Cara C. Wilson
Life of this patent
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Abstract
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.
Claims19
An immunogenic composition, comprising:
- a) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast spheroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and
- b) at least one antigen that is heterologous to the yeast vehicle and that is not expressed by or loaded into the yeast vehicle, and that has not been attached to the yeast vehicle, wherein the antigen is a T cell epitope presented by MHC Class I;
- wherein the composition elicits an MHC Class I cell-mediated immune response against the antigen.
2 more elements
A method to produce an immunogenic composition, comprising combining:
- a) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast spheroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and,
- b) at least one antigen that is heterologous to the yeast vehicle and that is not expressed by or loaded into the yeast vehicle, and that has not been attached to the yeast vehicle, wherein the antigen is a I cell epitope presented by MHC Class I.
1 more element
Dependencies are inferred from the claim text.