Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof

A compound having the following structural formula (I):

• in which A is a CH2 radical;
• B is a radical selected from among those of formulae (a) to (f):
• Ar is a radical selected from among those of formulae (g) to (i):
• wherein R3 is as defined below;
• R1 is a radical —OH, —OR4, —NHR5 or NR5R6, wherein R4, R5 and R6 are as defined below;
• R2 is a hydrogen, fluorine, chlorine or bromine atom, a linear or branched alkyl radical having 1 to 5 carbon atoms, a CF3, OR7, SR7, NHR8, NR8R9, 2-naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thiophenyl, CH2OR10 or CH2NR11R12 radical or a phenyl radical which is unsubstituted or substituted with at least one fluorine atom or with a methyl, ethyl, isopropyl, tert-butyl or CF3 radical, wherein R7, R8, R9, R10, R11 and R12 are as defined below;
• R3 is a hydrogen, fluorine or chlorine atom or a radical OH, OR13, CF3 or NR14R15, wherein R13, R14 and R15 are as defined below;
• R4 is a linear or branched alkyl radical having 1 to 4 carbon atoms;
• R5 is a hydrogen atom, an OH group or a linear or branched alkyl radical having 1 to 4 carbon atoms;
• R6 is a linear or branched alkyl radical having 1 to 4 carbon atoms;
• R7 is a hydrogen atom, a linear or branched alkyl radical having 1 to 6 carbon atoms, a radical CH2OR16 or a benzyl radical which is unsubstituted or substituted with at least one halogen atom, or with a methyl, ethyl, isopropyl, tert-butyl or CF3 radical, wherein R16 is as defined below;
• R8, R9, R11, R12, R14 and R15, which may be identical or different, are each a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms, (C═O)—R17 or (C═O)—OR17, wherein R17 is as defined below;
• R10 is a linear or branched alkyl radical having 1 to 4 carbon atoms or a benzyl or phenyl radical optionally substituted by one halogen atom, or by one alkyl radical having 1 to 3 carbon atoms;
• R13 is a methyl, ethyl or acetyl radical;
• R16 is a methyl, ethyl or CH2CH2OCH3 radical;
• R17 is a hydrogen atom or a linear or branched alkyl radical having 1 to 4 carbon atoms;
• and the stereoisomers and optical or geometrical isomers or mixtures thereof, and the salts obtained with a pharmaceutically acceptable acid or base.