Substituted aryl piperidinylalkynyladenosines as A2AR agonists

A compound of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 and R2 independently are selected from the group consisting of H, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C8)alkylene, aryl, aryl(C1-C8)alkylene, heteroaryl, heteroaryl(C1-C8)alkylene-, diaryl(C1-C8)alkylene, and diheteroaryl(C1-C8)alkylene, wherein the aryl and heteroaryl rings are optionally substituted with 1-4 groups independently selected from fluoro, chloro, iodo, bromo, methyl, trifluoromethyl, and methoxy;
• each R independently is selected from the group consisting of H, C1-C4 alkyl, cyclopropyl, cyclobutyl, and (CH2)acyclopropyl;
• X is CH or N, provided that when X is CH then Z cannot be substituted with halogen, C1-C6 alkyl, hydroxyl, amino, or mono- or di-(C1-C6-alkyl)amino;
• Y is selected from the group consisting of O, NR1, —(OCH2CH2O)mCH2—, and —(NR1CH2CH2O)mCH2—, provided that when Y is O or NR1, then at least one substituent is present on Z;
• Z is selected from the group consisting of 5-membered heteroaryl, 6-membered aryl, 6-membered heteroaryl, carbocyclic biaryl, and heterocyclic biaryl, wherein the point of attachment of Y to Z is a carbon atom on Z, wherein Z is substituted with 0-4 groups independently selected from the group consisting of F, Cl, Br, I, (C1-C4)alkyl, —(CH2)aOR3, —(CH2)aNR3R3, —NHOH, —NR3NR3R3, nitro, —(CH2)aCN, —(CH2)aCO2R3, —(CH2)aCONR3R3, trifluoromethyl, and trifluoromethoxy;
• alternatively, Y and Z together form an indolyl, indolinyl, isoindolinyl, tetrahydroisoquinolinyl, or tetrahydroquinolinyl moiety wherein the point of attachment is via the ring nitrogen and wherein said indolyl, indolinyl, isoindolinyl, tetrahydroisoquinolinyl, or tetrahydroquinolinyl moiety, which is substituted with 0-4 groups independently selected from the group consisting of F, Cl, Br, I, C1-C4 alkyl, —(CH2)aOR3, —(CH2)aNR3R3, —NHOH, —NR3NR3R3, NO2, —(CH2)aCN, —(CH2)aCO2R3, —(CH2)aCONR3R3, CF3, and OCF3;
• R3 is independently selected from the group consisting of H, (C1-C6)alkyl, cycloalkyl, aryl, and heteroaryl;
• R4 is selected from the group consisting of CH2OR, C(O)NRR, and CO2R;
• R5 is selected from the group consisting of CH2CH2, CH═CH, and C≡C;
• a is selected from 0, 1, and 2;
• m is selected from 1, 2, and 3;
• n is selected from 0, 1, and 2;
• each p independently is selected from 0, 1, and 2;
• and,
• q is selected from 0, 1, and 2.