AAV capsid library and AAV capsid proteins
AssigneeThe Board of Trustees of the Leland Stamford Junior University
InventorsMark Kay, Dirk Grimm
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Abstract
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided.
Claims3
An amino acid sequence selected from the group of sequences consisting of (i) sequences having at least 95% sequence identity over the entire length of SEQ ID NO:1 and (ii) SEQ ID NO:1.
A recombinant AAV vector, comprising a capsid protein having an amino acid sequence selected from the group of sequences consisting of (i) sequences having at least 95% sequence identity over the entire length of SEQ ID NO:1 and (ii) SEQ ID NO:
- 1.
A method of expressing a gene of interest in a mammal, comprising:
- introducing a recombinant AAV vector into a mammal, the recombinant AAV vector encoding for a gene of interest which is encapsidated into a capsid protein having an amino acid sequence selected from the group of sequences consisting of (i) sequences having at least 95% sequence identity over the entire length of SEQ ID NO:1 and (ii) SEQ ID NO:1.
Dependencies are inferred from the claim text.