Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders

A compound of formula (II):

• or a pharmaceutically acceptable salt, stereoisomer, or (C1-C6)alkyl ester thereof, wherein
• Q is aryl;
• represents a benzo-fused cyclopentyl ring;
• L2 is O;
• R1 is selected from (C2-C8)alkynyl, aryl, or —C(O)NR2R3;
• R2 and R3 are independently selected from hydrogen or (C1-C4)alkyl;
• R4 is independently selected from substituted (C1-C6)alkyl, —R′, —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, halogen, —OC(O)R′, —C(O)R′, —CO2R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR′—SO2NR″R′″, —NR″CO2R′, —NH—C(NH2)═NH, —NR′C(NH2)═NH, —NH—C(NH2)═NR′, —SiR′R″R′″, —S(O)R′, —SO2R′, —SO2NR′R″, —NR″SO2R, —CN, or —NO2, wherein R′, R″ and R′″ are each independently selected from hydrogen, unsubstituted (C1-C8)alkyl or heteroalkyl, unsubstituted aryl, aryl substituted with one to three halogens, unsubstituted alkyl, alkoxy or thioalkoxy groups, halo(C1-C4)alkyl, or aryl-(C1-C4)alkyl groups;
• R5 is independently selected from (C1-C6)alkyl, halogen, (C1-C6)alkoxy, cyano, or intro;
• the subscript n is 0, 1 or 2;
• and
• the subscript p is 0, 1, 2, 3 or 4.

A compound of formula (I):

• or a pharmaceutically acceptable salt, stereoisomer or (C1-C6)alkyl ester thereof, wherein
• Q is aryl;
• L1 is a bond;
• represents a benzo-fused cyclopentyl ring;
• L2 is O;
• M is an aromatic ring, (C5-C8)cycloalkylene, or aryl(C1-C4)alkylene;
• X is CR1R1′;
• L3 is a (C1-C5)alkylene or (C2C5)heteroalkylene;
• A is —CO2H, —SO3H, —PO3H2, —SO2NH2, —C(O)NHSO2CH3, —CHO, or hydroxyphenyl;
• R1 is (C2-C8)alkenyl, (C2-C8)alkynyl, or —C(O)NR2R3;
• R1′ is hydrogen, cyano, aryl, (C1-C8)alkyl, (C2-C8)alkenyl, or (C2-C8)alkynyl;
• and
• R2 and R3 are independently selected from hydrogen, aryl, (C1-C8)alkyl, (C2-C8)heteroalkyl, or (C3-C8)cycloalkyl.