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US 7,582,799 B2Granted
Method for producing hydrazone derivatives
AssigneesShiratori Pharmaceutical Co., Ltd., Asubio Pharma Co., Ltd.
InventorsHiroshi Yoshino, Kentaro Kobayashi, Yuichi Shiro
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Abstract
The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula.
Claims4
A process for producing a 1,1-bis-alkylsulfonyl compound represented by the general formula (2)
- (wherein R1 represents an alkyl group),
- comprising:
- reacting a 1,1-bis-alkylsulfanyl compound represented by the general formula (1)
- (wherein, R1 is the same as defined above)
- with a monopersulfate.
2 more elements
A process for producing an aldehyde compound represented by the general formula (3)
- comprising:
- reacting a 1,1-bis-alkylsulfanyl compound represented by the general formula (1)
- (wherein R1 represents an alkyl group)
- with a monopersulfate to produce a 1,1-bis-alkylsulfonyl compound represented by the general formula (2)
- (wherein, R1 is the same as defined above);
- and reacting the resultant 1,1-bis-alkylsulfonyl compound (2) with ammonia.
3 more elements
A process for producing a hydrazone derivative represented by the general formula (5)
- (wherein R2 and R3, which may be the same or different from each other represent an hydrogen atom, an alkyl group, or an aryl group), comprising:
- reacting a 1,1-bis-alkylsulfanyl compound represented by the general formula (1)
- (wherein R1 represents an alkyl group)
- with a monopersulfate to produce a 1,1-bis-alkylsulfonyl compound represented by the general formula (2)
- (wherein R1 is the same as defined above)
- and reacting the resultant 1,1-bis-alkylsulfonyl compound (2) with ammonia to produce an aldehyde compound represented by the general formula (3)
- and reacting with the resultant aldehyde compound (3) with a hydrazine compound represented by the formula (4)
- (wherein R2 and R3 are the same as defined above).
5 more elements
Dependencies are inferred from the claim text.