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US 7,582,797 B2Granted
Derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) and compositions comprising the same
AssigneeInstitute National de la Sante et de la Recherche Medicale (INSERM)
InventorsBernard Pierre Roques, Nicolas Inguimbert, Marie-Claude Fournie-Zaluski, Pierre Corvol, Catherine Llorens-Cortes
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Abstract
The invention relates to derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.
Claims16
Compound characterized in that it corresponds to formula (1)
- in which
- each group R1 is identical to the other group R1 and represents:
- a C1 to C6 alkyl, C2 to C6 alkenyl or C2 to C6 alkynyl group,
- a (CH2)nbenzyl group in which n is equal to 0 or 1,
- a (CH2)m(C3 to C6 cycloalkyl) group in which m is equal to 0 or 1,
- each of the alkyl, alkenyl, alkynyl, benzyl or cycloalkyl groups being substituted with one or two group(s) represented by the group A;
- the group A represents:
- a carboxylate group COOH or COOR, R representing a C1 to C6 alkyl or CH2phenyl group;
- a sulfonate group SO3H or SO3R′, R′ representing a C1 to C6 alkyl or CH2phenyl group;
- a phosphonate group PO3H2 or PO3R2″R′″, R″ and R′″ independently representing H, or a C1 to C6 alkyl or CH2phenyl group;
- each group R2 is identical to the other group R2 and represents a C1 to C6 alkyl, C2 to C6 alkenyl or C2 to C6 alkynyl group, each alkyl, alkenyl or alkynyl group being free or substituted with the group B;
- the group B represents:
- a carboxylate group, COOH or COOR′, R′ representing a C1 to C6 alkyl or CH2phenyl group;
- a phenyl group that is free or substituted with one or more radicals chosen from a halogen atom, an optionally protected hydroxyl radical, a C1 to C4 alkyl group, a cyano group, a free, salified or esterified carboxyl group or an amide group;
- each group R3 is identical to the other group R3 and represents a hydrogen atom.
12 more elements
Dependencies are inferred from the claim text.