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US 7,582,794 B2Granted
Process for the preparation of substituted 2-(phenoxymethyl)benzoic acids
AssigneeSanofi-Aventis Deutschland GmbH
InventorsWolfgang Fiedler, Bernd Neises, Jochen Hachtel
Life of this patent
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Abstract
The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and b) the compound (IV) formed as intermediate in step a) is reacted in the presence of a base B2 with a compound (V) to give the compound of the general formula (I)
Claims3
A compound of formula (IV)
- wherein
- X1 is halogen, C1-C6-alkyl, C1-C6-alkoxy, trifluoromethyl, aryl, heterocyclyl or heteroaryl,
- wherein said aryl, heterocyclyl and heteroaryl may in turn be at least monosubstituted by C1-C3-alkyl, C1-C3-alkoxy, halogen or trifluoromethyl;
- X2 is C1-C6-alkyl, trifluoromethyl, aryl, heterocyclyl or heteroaryl,
- wherein said aryl, heterocyclyl and heteroaryl may in turn be at least monosubstituted by C1-C3-alkyl, C1-C3-alkoxy, halogen or trifluoromethyl;
- wherein heteroaryl is a 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13 or 14-membered, aromatic, mono-, bi- or tricyclic heterocycle which contains one or more heteroatoms selected from N, O and S;
- wherein aryl is a 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13 or 14-membered, aromatic mono-, bi- or tricyclic system;
- wherein heterocyclyl is a 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13 or 14-membered, nonaromatic, mono-, bi- or tricyclic heterocycle which contains one or more heteroatoms selected from N, O and S;
- m is 0, 1, 2, 3 or 4;
- and
- n is 1, 2, 3 or 4;
- with the proviso that the compound of formula IV cannot be 2-(3-hydroxy-4-methoxyphenoxymethyl)benzoic acid.
9 more elements
Dependencies are inferred from the claim text.