Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
AssigneeEukarion, Inc.
InventorsBernard Malfroy-Camine, Susan Robin Doctrow
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Abstract
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
Claims20
A salen-metal compound having antioxidant activity and having a structural formula of Structure XXIII or Structure XXIV as shown in FIG. 26E, wherein:
- M is selected from the group consisting of Mn, Co, Fe, V, and Cr;
- A is an axial ligand selected from the group consisting of Cl, F, O, Br and acetyl;
- X2, X3 and X4 are independently selected from the group consisting of hydrogen, lower alkoxy, halide and aryloxy;
- Y2, Y3 and Y4 are independently selected from the group consisting of hydrogen, lower alkoxy, halide and aryloxy;
- and
- R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, aryl, substituted aryl, heteroatom-bearing aromatic, arylalkyl, lower alkoxy and halide and wherein one of R1 and R2 is optionally covalently linked to one of R3 and R4 thereby forming a cyclic structure.
Dependencies are inferred from the claim text.