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US 7,582,773 B2Granted
Substituted phenyl indoles
AssigneeWyeth
InventorEric Gould Gundersen
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to substituted phenyl indoles and methods of using them, for example as PAI-1 inhibitors.
Claims26
A compound of the formula:
- or a pharmaceutically acceptable salt or ester form thereof, wherein
- R1 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, aryl, or arylalkyl;
- R2 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, aryl, or arylalkyl;
- or R1 and R2 form a C5-C8 carbocyclic ring;
- R3, R4 and R5 are, independently, hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, halogen, hydroxy, C6-C14 aryl, C1-C3 perfluoroalkyl, C1-C3 alkoxy, or C1-C3 perfluoroalkoxy;
- R6 is hydrogen, C1-C6 alkyl, C1-C6 arylalkyl, C1-C6 alkanoyl, or aroyl;
- R7 is hydrogen;
- n is an integer of 0-6;
- and
- A is COOH, or an acid mimic.
7 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt or ester form thereof, wherein:
- R1 is, independently, C3-C8 cycloalkyl, and R2 is, independently, hydrogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, C6-C14 aryl, or arylalkyl;
- or R1 is, independently, hydrogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, C6-C14 aryl, or arylalkyl and R2 is, independently, C1-C6 perfluoroalkyl, or C3-C8 cycloalkyl;
- or R1 is, independently, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, or unsubstituted aryl, and R2 is, independently, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, or unsubstituted aryl;
- or R1 and R2 form a C5-C8 carbocyclic ring;
- R3, R4 and R5 are, independently, hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, halogen, hydroxy, C6-C14 aryl, C1-C3 perfluoroalkyl, C1-C3 alkoxy, or C1-C3 perfluoroalkoxy;
- R6 is hydrogen, C1-C6 alkyl, C1-C6 arylalkyl, C1-C6 alkanoyl, or aroyl;
- R7 is hydrogen;
- n is an integer of 0-6;
- and
- A is OOOH or an acid mimic.
8 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt or ester form thereof, wherein:
- R1 is C1-C6 perfluoroalkyl or C3-C8 cycloalkyl, and R2 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, C6-C14 aryl, or arylalkyl;
- or R1 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, C6-14 aryl, or arylalkyl and R2 is C1-C6 perfluoroalkyl or C3-C8 cycloalkyl;
- or R1 and R2 are hydrogen;
- or R1 and R2 form a C5-C8 carbocyclic ring;
- R3, R4 and R5 are, independently, hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, halogen, hydroxy, C6-C14 aryl, C1-C3 perfluoroalkyl, C1-C3 alkoxy, or C1-C3 perfluoroalkoxy;
- R6 is hydrogen, C1-C6 alkyl, C1-C6 arylalkyl, C1-C6 alkanoyl, or aroyl;
- R7 is hydrogen;
- n is an integer of 0-6;
- and
- A is OOOH, or an acid mimic.
8 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt or ester form thereof, wherein:
- R1 is, independently, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, C6-C14 aryl, or arylalkyl and R2 is, independently, hydrogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, C6-C14 aryl, or arylalkyl;
- or R1 is, independently, C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, arylalkyl, or aryl, and R2 is, independently, hydrogen, C1-C6 perfluoroalkyl, C3-C8 cycloalkyl, or aryl;
- or R1 and R2 form a C5-C8 carbocyclic ring;
- R3, R4 and R5 are, independently, hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, halogen, hydroxy, C6-C14 aryl, C1-C3 perfluoroalkyl, C1-C3 alkoxy, or C1-C3 perfluoroalkoxy;
- R6 is hydrogen, C1-C6 alkyl, C1-C6 arylalkyl, C1-C6 alkanoyl, or aroyl;
- R7 is hydrogen;
- n is an integer of 0-6;
- and
- A is an acid mimic.
7 more elements
Dependencies are inferred from the claim text.