Aryl aniline β2 adrenergic receptor agonists

A method of treating a pulmonary disease in a mammal, wherein the pulmonary disease is asthma or chronic obstructive pulmonary disease, the method comprising administering to the mammal a therapeutically-effective amount of a compound of formula (IIa):

• wherein:
• R4 is —CH2OH or —NHCHO and R5 is hydrogen;
• or R4 and R5 taken together are —NHC(═O)CH═CH—;
• R11 is phenyl or heteroaryl, wherein each phenyl is optionally substituted with 1 or 2 substituents selected from halo, —ORd, —CN, —NO2, —SO2Rd, —C(═O)Rd, —C(═O)NRdRe, and C1-3alkyl, wherein C1-3alkyl is optionally substituted with 1 or 2 substituents selected from carboxy, hydroxy, and amino, and each Rd and Re is independently hydrogen or C1-3alkyl;
• and wherein each heteroaryl is optionally substituted with 1 or 2 C1-3alkyl substituents;
• and
• R12 is hydrogen or —OC1-6alkyl;
• or a pharmaceutically-acceptable salt or stereoisomer thereof;
• and a therapeutically-effective amount of a corticosteroid selected from 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-[(4-methyl-1,3-thiazole-5-carbonyl)oxy]-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester and 6α,9α-difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester.