Nucleic acids and polypeptides of C1 bacteriophage and uses thereof
AssigneeThe Rockefeller University
InventorsVincent Fischetti, Daniel Nelson, Raymond Schuch
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Abstract
The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application. The specific regions of the C1 genome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.
Claims2
An isolated polypeptide comprising an amino acid sequence of a C1 bacteriophage PlyC lytic enzyme, wherein the polypeptide is a subunit PlyC lysin heavy chain (PlyC-A) and, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.