Methods and compositions for treating mammalian spinal cord injuries
AssigneesPurdue Research Foundation, The United States of America as represented by the Secretary of the Army, National Science Foundation
InventorsRiyi Shi, Richard B. Borgens
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Abstract
Methods of treating an injured vertebrate spinal cord are described. In one aspect of the invention, a method of treating an injured vertebrate spinal cord includes contacting the spinal cord with a biomembrane fusion agent such as a polyalkylene glycol, especially polyethylene glycol. In alternative embodiments of the invention, methods of treating an injured vertebrate spinal cord include contacting the cord with a biomembrane fusion agent and a potassium channel blocker. Other aspects of the invention include compositions for treating a vertebrate nervous system. A preferred composition includes a biomembrane fusion agent, such as a polyalkylene glycol, and a potassium channel blocker, such as an amino-substituted pyridine.
Claims14
A method of treating a mammalian patient having suffered an injury to its spinal cord, said method comprising contacting the injured spinal cord after the injury but within a period no greater than about 24 hours after said injury with a composition comprising an effective amount of at least one C1-C10 polyalkylene glycol, wherein the effective amount of at least one C1-C10 polyalkylene glycol is effective to restore nerve impulse conduction through said injured spinal cord, and wherein the effective amount of at least one C1-C10 polyalkylene glycol is at least about 40% by weight in the composition.
A method of treating a mammalian patient having suffered an injury to its spinal cord, said method comprising contacting the injured spinal cord after the injury but within a period no greater than about 24 hours after said injury with a composition comprising an effective amount of polyethylene glycol, wherein the effective amount of polyethylene glycol is effective to restore nerve impulse conduction through said injured spinal cord and wherein the effective amount of polyethylene glycol is at least about 40% by weight in the composition.
Dependencies are inferred from the claim text.