Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates
AssigneePharmaceutics International, Inc.
InventorsEmadeldin Hassan, Sridhar Gumudavelli, David Goldman
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Abstract
The present invention is directed to a solid ibuprofen concentrate composition and method of producing the composition. The solid ibuprofen concentrate contains (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and is characterized in that at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt.
Claims38
A composition comprising a solid ibuprofen concentrate, wherein the solid ibuprofen concentrate comprises (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and wherein at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt.
A method of manufacturing a solid ibuprofen concentrate, wherein at least 90% of the weight of the ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt, comprising:
- (a) mixing an ibuprofen free acid with a first alkaline substance to form a first composition,
- (b) mixing the first composition with a second alkaline substance to form a second composition, and
- (c) drying the second composition to produce a solid ibuprofen concentrate.
A composition comprising a solid ibuprofen concentrate, wherein the solid ibuprofen concentrate comprises (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and wherein at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt, wherein the ibuprofen alkali salt is produced from a solid ibuprofen free acid using at least two alkaline substances.
Dependencies are inferred from the claim text.