Therapeutic use of N-(1H-indolyl)-1H-indole-2-carboxamide derivatives

A method of treating a disease selected from the group consisting of chronic inflammatory pain, neuropathic pain, migraine and acute pain, comprising administering to a patient in need of said treatment a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:

• in which
• X1, X2, X3, X4, Z1, Z2, Z3, Z4 and Z5 represent, independently of one another, a hydrogen or halogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 fluoroalkyl, C1-C6 alkoxy, C1-C6 fluoroalkoxy, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6 thioalkyl, —S(O)—(C1-C6)alkyl, —S(O)2—(C1-C6)alkyl, SO2NR1R2, NR3COR4, NR3SO2R5 or aryl group;
• X5 represents a hydrogen or halogen atom or a C1-C6 alkyl or C1-C6 fluoroalkyl group;
• R represents a 4-, 5-, 6- or 7-indolyl group,
• R optionally being substituted in the 1, 2 or 3 position by one or more groups chosen from the C1-C6 alkyl and C1-C6 fluoroalkyl groups;
• R optionally being substituted in the 4, 5, 6 or 7 position by one or more groups chosen from halogen atoms or C1-C6 alkyl, C1-C6 fluoroalkyl, C1-C6 alkoxy or C1-C6 fluoroalkoxy groups;
• Y represents a hydrogen atom or a C1-C6 alkyl group;
• n is equal to 0, 1, 2 or 3;
• R1 and R2 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, (C3-C7)cycloalkyl(C1-C3)alkyl or aryl group;
• or
• R1 and R2 form, together with the nitrogen atom which carries them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine or homopiperazine group, said group optionally being substituted by C1-C6 alkyl, C3-C7 cycloalkyl, (C3-C7)cycloalkyl(C1-C3)alkyl or aryl group;
• R3 and R4 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl or aryl group;
• and
• R5 represents a C1-C6 alkyl or aryl group.