2-thio-substituted imidazole derivatives and their use in pharmaceutics

A 2-thio-substituted imidazole derivative compound of the formula I

• wherein
• R1 is aryl which is substituted by a halogen atom or by halo-C1-C6-alkyl;
• R2 is selected from the group consisting of
• a) aryl-C1-C4-alkyl, and
• b) C1-C6-alkyl;
• R3 selected from the group consisting of
• a) NR4R10,
• b) NR7COR10,
• c) OR10, and
• d) NH2;
• R4 is H, —COR14, —CO2R14, —CONH2, —CONHR14, —CHR16—OR14, —CHR16—O—COR14, —COC(R16)2—OH, —COR15, SO2R15 or —SO2R14, R14 is C1-C6-alkyl or CF3, R15 is phenyl or tolyl, and R16 is H or C1-C6-alkyl;
• R5 and R6, which may be identical or different, are H, halogen, C1-C6-alkoxy, C1-C6-alkyl or halo-C1-C6-alkyl;
• R7 is H;
• R10 has one of the meanings below:
• f) C1-C6-alkyl which is substituted by 2 phenyl groups, or
• g) trifluoromethyl;
• A is straight-chain or branched C1-C6-alkylene or C2-C6-alkenylene;
• B is selected from the group consisting of
• e) OC1-C6-alkyl, and
• f) OH;
• Hy is a 3- to 10-membered non-aromatic mono-, bi- or tricyclic carbocycle which may or may not be fused with a benzene ring;
• Ar is a 5- or 6-membered aromatic heterocycle which has 1, 2 or 3 heteroatoms independently of one another selected from the group consisting of O, S and N and which may or may not be fused with a benzene ring;
• Het is a 5- or 6-membered non-aromatic heterocycle which has 1, 2 or 3 heteroatoms independently of one another selected from the group consisting of O, S and N which may or may not be fused with a benzene ring and which may or may not be bridged bicyclically or tricyclically;
• m is 0, 1 or 2;
• or a tautomer, an optical isomer or a physiologically acceptable salt thereof.