Guanidine derivatives and therapeutic uses thereof

A compound of formula (I):

• wherein:
• R1 is in each case hydrogen, or (C1-C6)alkyl, or alternatively the two radicals R1 form, together with the carbon atom that bears them, (C3-C10)cycloalkyl;
• R2 is (C1-C10)alkyl, (C2-C10)alkenyl, (C6-C18)aryl(C1-C10)alkyl, (C1-C6)alkyl-O—(C1-C10)alkyl, or (C3-C10)cycloalkyl(C1-C10)alkyl;
• R3 and R4, which may be identical or different, are each, independently, hydrogen, (C1-C10)alkyl, (C2-C10)alkenyl, (C6-C18)aryl(C1-C10)alkyl, (C1-C6)alkyl-O—(C1-C10)alkyl, or (C3-C10)cycloalkyl(C1-C10)alkyl, or alternatively
• R3 and R4 form, together with the nitrogen atom that bears them, a 3- to 9-membered heterocycle;
• R5, R6, R7 and R8, which may be identical or different, are each, independently, hydrogen, (C1-C10)alkyl, a (C1-C10)alkenyl, (C1-C6)alkyl-O—;
• and
• R9 is hydrogen, and R10 is hydrogen or (C1-C6)alkyl, or alternatively
• R9 and R10 form, together with the nitrogen atom that bears them, a 3- to 7-membered heterocycle;
• wherein alkyl, aryl, and heterocyclic groups listed above are in each case unsubstituted or substituted one or more times by G;
• G is trifluoromethyl, styryl, halogen, Het which is unsubstituted or substituted one or more times by T, Het-CO— which is unsubstituted substituted one or more times by T, nitro, cyano, (C1-C10)alkyl, (C1-C10)alkylcarbonyl, (C1-C10)alkoxycarbonyl-A-, (C3-C10)cycloalkyl, trifluoromethoxy, di(C1-C10)alkylamino, (C1-C10)alkoxy(C1-C10)alkyl, (C1-C10)alkoxy, (C6-C18)aryl which is unsubstituted or substituted one or more times by T, (C6-C18)aryl(C1-C10)alkoxy-(CO)n— which is unsubstituted or substituted one or more times by T, (C6-C18)aryloxy(CO)n— which is unsubstituted or substituted one or more times by T, (C6-C18)arylthio in which aryl is unsubstituted or substituted one or more times by T, (C6-C18)aryloxy-(C1-C10)alkyl(CO)n— in which aryl is unsubstituted or substituted one or more times by T, monocyclic 5- to 8-membered heterocycle containing one or more hetero atoms chosen from O, N and S and which is unsubstituted or substituted one or more times by T, (C6-C18)aryl-carbonyl which is unsubstituted or substituted one or more times by T, (C6-C18)arylcarbonyl-B—(CO)n—, (C6-C18)aryl-C′—(CO)n— wherein aryl is unsubstituted or substituted one or more times by T, (C6-C18)aryl which is fused to a saturated or unsaturated heterocycle and which is unsubstituted or substituted one or more times by T, or (C2-C10)alkynyl;
• T is halogen, (C6-C18)aryl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkoxy-(C6-C18)aryl, nitro, carboxyl, (C1-C6)alkoxycarboxyl, (C1-C6)alkoxy-carbonyl(C1-C6)alkyl, or (C1-C6)alkylcarbonyl((C1-C6)alkyl)n—, or T can also be oxo in the case where it substitutes a saturated or unsaturated heterocycle, or if two vicinal carbon atoms are substituted, T can also be a C1-C6 alkylenediyl chain or a C1-C6 alkylenedioxy chain;
• Het is a monocyclic, bicyclic or tricyclic aromatic heterocyclic radical containing one or more hetero atoms chosen from O, N and S;
• A is (C1-C6)alkylene, (C2-C6)alkenylene or a bond;
• n is 0 or 1;
• B represents (C1-C6)alkylene or (C2-C6)alkenylene and aryl is optionally substituted by one or more radicals T;
• and
• C′ represents (C1-C6)alkylene or (C2-C6)alkenylene;
• or
• an optical or geometrical isomer thereof, an oxide form thereof, a tautomeric form thereof;
• or a pharmaceutically acceptable addition salt thereof.