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US 7,582,654 B2Granted
Heterocyclo inhibitors of potassium channel function
AssigneesBristol-Myers Squibb Company, Icagen, Inc.
InventorsJohn Lloyd, Yoon T. Jeon, Heather Finlay, Lin Yan, Michael F. Gross, Serge Beaudoin
Life of this patent
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Abstract
Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
Claims4
A compound of formula I
- enantiomers, diastereomers, and salts thereof wherein
- m and p are independently 0, 1, or 2 provided that the sum of m and p is 2;
- Q is NR1;
- R2 is aryl, which may be optionally independently substituted with one or more groups T1, T2 or T3;
- J is a bond or C1-4 alkylene optionally independently substituted with one or more groups T1a, T2a or T3a;
- R3 is —R5;
- R4 is alkyl or aryl, any of which may be optionally independently substituted with one or more groups T1b, T2b or T3b;
- R5 is —NR6aR7a;
- R6a is indazolyl, which may be optionally independently substituted with one or more groups T1d, T2d or T3d;
- R7a is H;
- RX is one or more optional substituents, attached to any available ring carbon atom, independently selected from T1g, T2g or T3g;
- T1-1g, T2-2g, and T3-3g are each independently hydrogen, alkyl, haloalkyl, aryl, —OH, —Oalkyl or halo.
9 more elements
Dependencies are inferred from the claim text.