Carboxylic acid derivatives, their preparation and use
AssigneeAbbott GmbH & Co. KG
InventorsHartmut Riechers, Dagmar Klinge, Wilhelm Amberg, Andreas Kling, Stefan Muller, Ernst Baumann, Joachim Rheinheimer, Uwe Josef Vogelbacher, Wolfgang Wernet, Liliane Unger, Manfred Raschack
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Abstract
Carboxylic acid derivatives where R—R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
Claims16
A method to treat a disease in a subject in need thereof, said method comprising administering to said subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula
- wherein:
- X is CH;
- Y is oxygen;
- Z is oxygen;
- R is CO2H;
- R2 methoxy;
- R3 is methoxy;
- R4 is phenyl;
- R5 is phenyl;
- and
- R6 is methyl,
- or an enantiomer thereof;
- wherein said disease is selected from the group consisting of hypertension, pulmonary hypertension, myocardial infarction, angina pectoris, acute kidney failure, renal insufficiency, cerebral vasospasms, cerebral ischemia, subarachnoid hemorrhages, asthma, atherosclerosis, intravascular coagulation, restenosis after angioplasty, hypertension caused by ischemia or intoxication, kidney failure caused by ischemia or intoxication, Raynaud's syndrome, and asthmatic airway condition.
A method to treat a disease in a subject in need thereof, said method comprising administering to said subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula
- wherein:
- X is CH;
- Y is oxygen;
- Z is oxygen;
- R is CO2H;
- R2 is methoxy;
- R3 is methoxy;
- R4 is phenyl;
- R5 is phenyl;
- and
- R6 is methyl,
- or an enantiomer thereof;
- wherein said disease is hypertension.
A method to treat a disease in a subject in need thereof, said method comprising administering to said subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula
- wherein:
- X is CH;
- Y is oxygen;
- Z is oxygen;
- R is C2H;
- R2 is methoxy;
- R3 is methoxy;
- R4 is phenyl;
- R5 is phenyl;
- and
- R6 is methyl,
- or an enantiomer thereof;
- wherein said disease is pulmonary hypertension.
Dependencies are inferred from the claim text.