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US 7,582,639 B2Granted
N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them
AssigneeIndena S.p.A.
InventorsEzio Bombardelli, Gabriele Fontana
Life of this patent
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Abstract
Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antiinflammatory, antiarthritic and antiviral activity.
Claims2
A compound of formula I
- wherein,
- the linker is piperazinyl,
- the junctions G1 and G2 are both —CO— or —CONH, and
- the linker is linked to G1 and G2 through two carbon atoms located at a carbon ring position selected from the group consisting of 3,5 of the ring, 2,5 of the ring, and 2,6 of the ring.
1 more element
Dependencies are inferred from the claim text.