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US 7,582,638 B2Granted
Pyrazole-isoquinoline urea derivatives as p38 kinase inhibitors
AssigneeEli Lilly and Company
InventorsAlfonso De Dios, Cristina Garcia-Paredes, Beatriz López de Uralde Garmendia, Mary Margaret Mader, Mark Andrew Pobanz, Chuan Shih, Boyu Zhong
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Abstract
The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.
Claims7
A compound of Formula I:
- where:
- X is selected from the group consisting of
- R1 is C1-C4 alkyl, C3-C4 cycloalkyl optionally substituted with one or two substituents selected from the group of C1-C4 alkoxy, methyl, and trifluoromethyl;
- or C1-C4 alkylhalo;
- R2 is phenyl optionally substituted with C1-C4 alkyl, or pyridinyl optionally substituted with C1-C4 alkyl;
- R3 is amino, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylhalo, C3-C4 cycloalkyl optionally substituted with a substituent selected from methyl, trifluoromethyl, or halo;
- phenyl or thienyl each optionally substituted with a first substituent selected from the group consisting of:
- halo, C1-C4 alkyl, and C1-C4 alkoxy, and optionally further substituted with a second substituent selected from halo;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.