Tri(cyclo) substituted amide compounds

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• Q is an aryl, a 5- or 6-membered heteroaryl, or a 4-8-membered heterocyclic ring;
• T together with the —N═C— to which it is attached forms a heteroaryl ring, or a heterocyclic ring where the N═C bond is the only site of unsaturation;
• R1 and R2 each independently are hydrogen, hydroxy, halogen, cyano, nitro, vinyl, ethynyl, methoxy, OCFnH3-n, —N(C0-4alkyl)(C0-4alkyl)-, CHO, or C1-2alkyl optionally substituted with 1-5 independent halogen, hydroxy, cyano, methoxy, —N(C0-2alkyl)(C0-2alkyl), SOCH3, or SO2CH3 substituents;
• or R1 and R2 together form a carbocyclic or heterocyclic ring;
• or R1 and R2 may be taken together to represent an oxygen atom attached to the ring via a double bond;
• R1 and R4 each independently are hydrogen, halogen, OCFnH3-n, methoxy, CO2R77, cyano, nitro, CHO, CONR99R100, CON(OCH3)CH3, or C1-2alkyl, heteroaryl, or C3-7cycloalkyl optionally substituted with 1-5 independent halogen, hydroxy, cyano, methoxy, —NHCO2CH3, or —N(C0-2alkyl)(C0-2alkyl) substituents;
• or R3 and R4 together form a 5-8-membered aromatic, heteroaromatic, carbocyclic, or heterocyclic ring;
• R5 is SO2C3-4cycloalkyl;
• R6 is hydrogen, hydroxy, halogen, cyano, nitro, CO2R7, CHO, COR8, C(OH)R7R8, C(═NOR7)R8, CONR9R10, SR7, SOR8, SO2R8, SO2NR9R10, CH2NR9R10, NR9R10, N(C0-4alkyl)SO2R8, NHCOR7, or C1-4alkyl group, C2-4alkenyl group, C2-4alkynyl group, C1-4alkoxy group, aryl group, or heteroaryl group, wherein any group optionally is substituted with 1-6 independent halogen, cyano, nitro, hydroxy, C1-2alkoxy, —N(C0-2alkyl)(C0-2alkyl), C1-2alkyl, CFnH3-n, aryl, heteroaryl, —COC1-2alkyl, —CON(C0-2alkyl)(C0-2alkyl), SCH3, SOCH3, SO2CH3, or —SO2N(C0-2alkyl)(C0-2alkyl) substituents;
• R7 and R77 each independently are hydrogen, or C1-4alkyl group, C2-4alkenyl group, C2-4alkynyl group, C3-7cycloalkyl group, aryl group, heteroaryl group, or 4-7-membered heterocyclic group, wherein any group optionally is substituted with 1-6 independent halogen, cyano, nitro, hydroxy, C1-2alkoxy, —N(C0-2alkyl)(C0-2alkyl), C1-2alkyl, C3-7cycloalkyl, 4-7-membered heterocyclic ring, CFnH3-n, aryl, heteroaryl, CO2H, —COC1-2alkyl, —CON(C0-2alkyl)(C0-2alkyl), SOCH3, SO2CH3, or —SO2N(C0-2alkyl-)(C0-2alkyl) substituents;
• R8 is C1-4alkyl group, C2-4alkenyl group, C2-4alkynyl group, C3-7cycloalkyl group, aryl group, heteroaryl group, or 4-7-membered heterocyclic group, wherein any group optionally is substituted with 1-6 independent halogen, cyano, nitro, hydroxy, C1-2alkoxy, —N(C0-2alkyl)(C0-2alkyl), C1-2alkyl, C3-7cycloalkyl, 4-7-membered heterocyclic ring, CFnH3-n, aryl, heteroaryl, CO2H, COC1-2alkyl, —CON(C0-2alkyl)(C0-2alkyl), SOCH3, SO2CH3, or —SO2N(C0-2alkyl)(C0-2alkyl) substituents;
• R9, R10, R99, and R100 each independently are hydrogen, or C1-4alkyl group, C3-7cycloalkyl group, aryl group, heteroaryl group, or 4-7-membered heterocyclic group, wherein any group optionally is substituted with 1-6 independent halogen, cyano, nitro, hydroxy, C1-2alkoxy, —N(C0-2alkyl)(C0-2alkyl), C1-2alkyl, C3-7cycloalkyl, 4-7-membered heterocyclic ring, CFnH3-n, aryl, heteroaryl, COC1-2alkyl, —CON(C0-2alkyl)(C0-2alkyl)-, SOCH3, SO2CH3, or —SO2N(C0-2alkyl)(C0-2alkyl) substituents;
• or R9 and R10 or R99 and R100 together form a 6-8-membered heterobicyclic ring system or a 4-8-membered heterocyclic ring which optionally is substituted with 1-2 independent C1-2alkyl, CH2OCH3, COC0-2alkyl, hydroxy, or SO2CH3 substituents;
• n is 1, 2 or 3;
• m is 0 or 1;
• and
• the dotted line together with the solid line forms an optional double bond, and A indicates that the double bond has the (L)-configuration;
• provided that when Q is 4-tetrahydropyranyl and the dotted line together with the solid line forms a single bond, then T together with the —N═C— to which it is attached is not 2-pyrazinyl or 2-thiazolyl wherein R3 and R4 are each independently hydrogen or fluoro.