Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
AssigneePfizer Italia S.r.l.
InventorsDaniele Fancelli, Barbara Forte, Jürgen Moll, Mario Varasi, Paola Vianello
Life of this patent
Estimating the term…
Abstract
Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Claims6
A method for treating cell proliferative disorders caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I)
- wherein
- R is hydrogen or methyl;
- R1 is an alkoxy group;
- R2 is a hydrogen or halogen atom;
- X is a divalent group selected from methylene (—CH2—) or fluoromethylene (—CHF—), or it is a heteroatom or heteroatomic group selected from oxygen (—O—) or nitrogen (—NR′—) wherein R′ is a hydrogen atom, a straight or branched C1-C4 alkyl group or a C3-C6 cycloalkyl group;
- or a pharmaceutically acceptable salt thereof;
- wherein said cell proliferative disorders are selected from the group consisting of benign prostate hyperplasia, familial adenomatosis polyposis, neuro-fibromatosis, melanoma, teratocarcinoma, xeroderma pigmentosum, keratoxanthoma, Kaposi's sarcoma, colon cancer, lung cancer, osterosarcoma, hematopoietic tumors of myeloid or lymphoid lineage, mesothelioma, kidney cancer, breast cancer, ovary cancer, pancreas cancer, prostate cancer, thyroid, and cervix cancer.
Dependencies are inferred from the claim text.