Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions

A compound of the formula I

• wherein
• R1 denotes a group of the formula
• wherein
• R1.1 denotes H or H3C—O—,
• R2 denotes a group of the formula II
• wherein
• R2.1 denotes HO, H3CO, H—C(O)—O or H3C—C(O)—O— and
• R2.2 denotes C1-2-alkyl or H3CO—,
• R3 denotes R4—C2-8-alkylene-NH— and
• R4 denotes H, H2N, C1-3-alkyl-NH, (C1-3-alkyl)2—N or C1-6-alkyl-O—C(O)—NH— or
• R3 denotes a group of the formulae
• wherein
• R3.2 denotes H or C1-3-alkyl,
• R3.3 denotes a free electron pair or an oxygen atom,
• R3.4 denotes H or C1-3-alkyl and
• R4 denotes H, C1-6-alkyl, H2N—C2-6-alkylene, C1-3-alkyl-NH—C2-6-alkylene, (C1-3-alkyl)2—N—C1-6-alkylene, C3-6-cycloalkyl-C1-3-alkylene, NH2, C1-3-alkyl-NH or (C1-3-alkyl)2—N, or
• R4 denotes a group selected from
• R4 denotes a group of the formulae
• wherein
• X denotes C and
• R4.1 denotes H, OH or C1-3-alkyl or
• X denotes N and
• R4.1 denotes a free electron pair or an oxygen atom,
• Y denotes O, S, S(O), S(O)2, if X═N, or
• Y denotes S, S(O), S(O)2, if X═C,
• R4.2 denotes H or C1-3-alkyl,
• R4.3 denotes H or C1-3-alkyl,
• R4.4 denotes a free electron pair or, if R5.2 is not H or C1-3-alkyl-C(O)—, an oxygen atom,
• R5.1 denotes H, CN, OH, C1-3-alkyl, C1-3-alkyl-C(O)—O, C1-3-alkyl-O, R5.1,1-O—C(O), R5.1,1-O—C(O)-C2-4-alkylene or R5.1,1-C(O)—C1-3-alkylene-O,
• R5.1.1 denotes H, C1-6-alkyl, H2N—C(O)—C1-3-alkylene, C1-3-alkyl-NH—C(O)—C1-3-alkylene, (C1-3-alkyl)2—N—C(O)—C1-3-alkylene or C1-3alkyl-O—C(O)—O—C1-3alkylene,
• R5.2 denotes H, C1-3-alkyl, C3-6-cycloalkyl, C3-6-cycloalkyl-C1-3-alkylene, C1-3-alkyl-C(O), R5.2.1—O—C(O)—C1-3-alkylene or R5.2.2—C2-4-alkylene-O—C(O)—C1-3-alkylene,
• R5.2.1 denotes H, C1-6-alkyl, C1-6-alkyl-C(O)—O—C1-3-alkylene, C1-3-alkyl-O—C(O)—O—C1-3-alkylene, C3-7-cycloalkyl-O—C(O)—O—C1-3-alkylene, H2N—C(O)—C1-3-alkylene, C1-3-alkyl-NH—C(O)—C1-3-alkylene, (C1-3-alkyl)2—N—C(O)—C1-3-alkylene or R5.2.1,1-C(O)—C1-3-alkylene and
• R5.2.1.1 denotes a group selected from
• R5.2.1 denotes a group selected from
• R5.2.2 denotes H2N, C1-3-alkyl-NH, (C1-3-alkyl)2—N, C1-3-alkyl-O or C1-3-alkyl-O—C2-4-alkylene-O, or
• R5.2.2 denotes a group selected from
• with the proviso that R3 and R4 are not bound to one another simultaneously via an N atom,
• or a tautomer or salt thereof.