US 7,582,619 B2 · Compositions and methods for treatment of mitochondrial diseases

Abstract

Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

Claims4

Dependent claims

A method for reducing side effects of cytotoxic cancer chemotherapy agents by administering a pyrimidine nucleotide precursor, where said cytotoxic cancer chemotherapy agent is not a pyrimidine nucleoside analog.

Dependencies are inferred from the claim text.

Facts

Application

11/520,811Filed 14 Sep 2006 · continuation

Priority

31 Aug 1998

Published

US 2007/0010479 A111 Jan 2007

Granted

1 Sep 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification29 codes

A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 31/70
Medicinal preparations containing organic active ingredients: carbohydrates; Sugars; Derivatives thereof
A61K 31/7068
Containing condensed or non-condensed pyrimidines: having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

Family

Application09/144,096Parent of this continuation · filed 31 Aug 1998

Application09/838,136Parent of this division · filed 20 Apr 2001

Application11/127,171Parent of this continuation · filed 12 May 2005

US 2007/0010479 A1Pre-grant publication · published 11 Jan 2007

US 6,956,028 B2Parent of this division

Application11/127,171Parent of this division

US 6,472,378 B2Parent of this continuation

Application09/838,136Parent of this continuation

US 2001/0005719 A1Published application

US 2001/0016576 A1Published application

US 2005/0203066 A1Published application

US 7,582,619 B2This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

11/520,811Filed 14 Sep 2006 · continuation

Priority

31 Aug 1998

Published

US 2007/0010479 A111 Jan 2007

Granted

1 Sep 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification29 codes

A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 31/70
Medicinal preparations containing organic active ingredients: carbohydrates; Sugars; Derivatives thereof
A61K 31/7068
Containing condensed or non-condensed pyrimidines: having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

Family

Application09/144,096Parent of this continuation · filed 31 Aug 1998

Application09/838,136Parent of this division · filed 20 Apr 2001

Application11/127,171Parent of this continuation · filed 12 May 2005

US 2007/0010479 A1Pre-grant publication · published 11 Jan 2007

US 6,956,028 B2Parent of this division

Application11/127,171Parent of this division

US 6,472,378 B2Parent of this continuation

Application09/838,136Parent of this continuation

US 2001/0005719 A1Published application

US 2001/0016576 A1Published application

US 2005/0203066 A1Published application

US 7,582,619 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions and methods for treatment of mitochondrial diseases

Life of this patent

Abstract

Claims4

Compositions and methods for treatment of mitochondrial diseases

Life of this patent

Abstract

Claims4