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US 7,582,613 B2Granted
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
AssigneeVical Incorporated
InventorCarl J Wheeler
Life of this patent
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Abstract
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
Claims10
A method for prophylactically or therapeutically treating an infectious disease of a mammal, comprising administering to the mammal an immunogenic composition comprising:
- (a) one or more immunogen-encoding polynucleotides of a mammalian influenza virus, and
- (b) an adjuvant composition comprising a (±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(syn-9-tetradeceneyloxy)-1-propanaminium salt and one or more co-lipids;
- wherein said immunogen is expressed in the mammal in an amount sufficient to generate an immune response to the immunogen;
- and
- wherein said infectious disease is a mammalian influenza viral infection.
2 more elements
Dependencies are inferred from the claim text.