Multi-action anthelmintic formulations
AssigneesThe Hartz Mountain Corporation, Virbac
InventorsAlbert Ahn, Ian Cottrell
Life of this patent
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Abstract
The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus tetrahydropyrimidines. An examples of a tetrahydropyrimidine includes pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.
Claims22
A method for forming an anthelmintic formulation comprising the steps of:
- preparing a combination of ivermectin, an alcohol, and a second material, wherein the second material comprises polyethylene glycol;
- then
- spray granulating the combination to form granules, with the polyethylene glycol covering the ivermectin, and
- combining the granules with an additional active ingredient composition.
A method for forming an anthelmintic formulation, comprising the steps of:
- a) preparing a first preparation comprising an avermectin, polyethylene glycol, and water;
- b) preparing a second preparation comprising a tetrahydropyrimidine and water, wherein the avermectin and tetrahydropyrimidine preparations together comprise an anthelmintic combination
- c) separately forming solids from the first and second preparations, said solid forming step comprising spray granulating the first preparation with the polyethylene glycol covering the avermectin;
- and
- d) combining the solid preparations to form an anthelmintic solid, consisting essentially of the avermectin and the tetrahydropyrimidine, with one or more appropriate excipients to provide the combinations in a form suitable to be administered to a mammal.
A method for forming an anthelmintic formulation comprising the steps of:
- a) preparing a first preparation comprising an avermectin, polyethylene glycol and an alcohol;
- b) preparing a second preparation comprising a tetrahydropyrimidine and an alcohol, wherein the avermectin and tetrahydropyrimidine preparations together comprise an anthelmintic combination
- c) separately forming solids from the first and second preparations, said solid forming step comprising spray granulating the first preparation with the polyethylene glycol covering the avermectin;
- and
- d) combining the solid preparations to form an anthelmintic solid, consisting essentially of the avermectin and the tetrahydropyrimidine, with one or more appropriate excipients to provide the combinations in a form suitable to be administered to a mammal.
Dependencies are inferred from the claim text.