Motilide compounds

A compound having a structure represented by formula (I)

• and the pharmaceutically acceptable salts, solvates, and hydrates thereof,
• wherein
• (A) RA is
• (i) OR1;
• (ii) O(CH2)mC(═O)R2;
• (iii) OC(═O)R4;
• (iv) OS(O2)N(R3R3A);
• (v) O(CH2)nNHR5;
• (vi) N(H)S(O2)R6;
• (vii) OCH2CH2OCH2CH2C(═O)R2;
• or
• (viii) OCH2CH2OCH2CH2NHR5;
• (B) RB is selected from the group consisting of C2-C4 alkyl, C3-C4 alkenyl, or C3-C4 alkynyl, 3- or 4-membered cycloaliphatic, and 3- or 4-membered heterocycloaliphatic, each member of the group being optionally substituted with one or more substituents selected from the group consisting of OH, CN, and halogen;
• (C) RC is H or OH;
• (D) RD is H or Me;
• (E) RE is H or OH;
• and
• (F) RF is H or Me;
• wherein
• R1 is C1-C4 alkyl, which C1-C4 alkyl is optionally substituted with OH, CN, O(C1-C3 alkyl), halogen, aryl, cycloaliphatic, heteroaryl, or heterocycloaliphatic, said aryl, cycloaliphatic, heteroaryl and heterocycloaliphatic moieties being optionally substituted with C1- C4 alkyl;
• R2 is OR3, N(R3R3A), C1-C4 alkyl, (CH2)nOH, or C2-C4 haloalkyl;
• R3 is H, C1-C4 alkyl, or (CH2)nOH;
• R3A is H, C1-C4 alkyl, (CH2)nOH, (CH2)nO(C1-C2 alkyl), C2-C4 haloalkyl, C1-C4 alkyl(aryl), C1-C4 alkyl(heteroaryl), O(C1-C4 alkyl), heteroaryl, or
• wherein
• X is N or CH;
• Y is O, S, NH, N(C1-C3 alkyl), CH2, or a bond;
• each p is (i) independently 1 or 2 when X is CH2;
• (ii) 2 when X is N and Y is other than CH2 or a bond;
• and (iii) independently 1 or 2 when X is N and Y is CH2 or a bond;
• and
• q is (i) 0, 1, 2, or 3 when X is CH and (ii) 2 or 3 when X is N;
• R4 is N(R3R3A) or C1-C4 alkyl;
• R5 is S(O2)(C1-C4 alkyl), C(═O)(C1-C4 alkyl), C(═O)aryl, C(═O)(heteroaryl ), C(═O)H, or C(═W)NH(C1-C4 alkyl), where W is O or S;
• R6 is C1-C4 alkyl, cyclobutyl, cyclopropyl, CF3, or N(R3R3A);
• m is 1, 2, 3, 4, 5, or 6;
• and
• n is, independently for each occurrence thereof, 2, 3 or 4.