Muteins of fibroblast growth factor 21
AssigneeEli Lilly and Company
InventorsChristopher Carl Frye, Lihua Huang, Radmila Micanovic
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Abstract
The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced capacity of O-glycosylation when expressed in yeast compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.
Claims3
A mutein of human FGF-21 consisting of human FGF-21 containing 1 engineered disulfide bond and a substitution of Ser 167 with Ala, wherein the numbering of amino acids is based on SEQ ID NO:1 and said mutein is Δ(His1Pro2Ile3Pro4)-Leu118Cys-Ala134Cys-Ser167Ala-human FGF-21.
Dependencies are inferred from the claim text.