Double resonance interrogation of grating-coupled waveguides
AssigneeCorning Incorporated
InventorsJacques Gollier, Eric J. Mozdy, Garrett A. Piech
Life of this patent
Estimating the term…
Abstract
A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical agents, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations. Also described is an optical interrogation system incorporating the method.
Claims12
A method for interrogating a sensor, said method comprising the steps of:
- emitting a single light beam towards said sensor, where said emitted single light beam has enough angular/wavelength spread to simultaneously excite a forward propagating direction and a backward propagating direction within a waveguide of said sensor;
- receiving a single light beam from said sensor, where said received single light beam has a positive resonance and a negative resonance for a given superstrate refractive index on said sensor;
- and
- using both the positive resonance and the negative resonance within the received single light beam to obtain a signal which is used to indicate whether or not a biological or chemical agent is located on said sensor.
A method for interrogating a sensor, said method comprising the steps of:
- providing the sensor which has a evanescent-field sensing region comprising a substrate surface having at least a bio- or chemo-responsive layer;
- exposing the sensing region to an analyte;
- emitting a single light beam towards said sensor to generate a double resonance by exciting a forward propagating direction and a backward propagating direction within a waveguide of said sensor;
- receiving a single light beam containing the double resonance out-coupled from said sensor;
- and
- using the double resonance within the received single light beam to obtain a signal which is used to monitor a response from said sensor.
Dependencies are inferred from the claim text.