Cleaved serum response factor in cardiac diagnosis and therapy
AssigneeBaylor College of Medicine
InventorsRobert J. Schwartz, Lei Wei, Jiang Chang, Mark Entman
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Abstract
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiments, heart failure is associated with cardiac myocyte apoptosis as a result of an increase in cleaved serum response factor, particularly by caspases.
Claims10
A method of diagnosing cardiac disease resulting from apoptosis in an individual, comprising the step of identifying cleavage of SRF in at least one cardiac cell from a sample from said individual, wherein identifying said SRF cleavage fragment indicates a diagnosis of cardiac disease resulting from apoptosis.
Dependencies are inferred from the claim text.