Polynucleotide encoding an IL-29 polypeptide
AssigneeZymoGenetics, Inc.
InventorsLowell J. Brady, Kevin M. Klucher, Chung Chan, Dennis L. Dong, Hong Y. Liu, Paul O. Sheppard, Thomas R. Bukowski
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Abstract
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
Claims8
An isolated polynucleotide encoding a polypeptide wherein the encoded polypeptide comprises amino acid residues 1-175 of SEQ ID NO:149.
An isolated polynucleotide comprising nucleotides 1-528 of SEQ ID NO:148.
Dependencies are inferred from the claim text.