Methods and compositions for using aleveolar macrophage phospholipase A2
AssigneeThe Regents of the University of Michigan
InventorsJames A. Shayman, Akira Abe, Miki Hiraoka
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Abstract
The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
Claims3
A method of increasing degradation of glycerophospholipids in pulmonary surfactant comprising contacting a sample containing pulmonary surfactant with a composition comprising a lysosomal phospholipase A2 (LPLA2) protein having the amino acid sequence of SEQ ID NO:2, or an enzymatically active fragment of the protein having the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.