Methods and compositions for treating and diagnosing disease
AssigneeCelera Corporation
InventorsSteve Ruben, Candy N. Lee, Bruno Domon
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Abstract
Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
Claims3
A method of diagnosing lung cancer in a subject, the method comprising detecting a higher level of Na-K ATPase beta3 protein in a sample from the subject's lung as compared to the level of Na-K ATPase beta3 protein in samples from healthy subject's lungs, wherein the higher level of Na-K ATPase beta3 protein indicates that said subject has lung cancer, and wherein the amino acid sequence of the Na-K ATPase beta3 protein comprises a sequence selected from group consisting of SEQ ID NOS:127-134.
Dependencies are inferred from the claim text.