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US 7,582,440 B2Granted
Imaging, diagnosis and treatment of disease
AssigneeCancer Research Technology Limited
InventorsRoy Bicknell, Lukasz Huminiecki
Life of this patent
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Abstract
The present invention relates to endothelial cell-specific genes and encoded polypeptides and materials and uses thereof in the imaging, diagnosis and treatment of conditions involving the vascular endothelium.
Claims15
A method of detecting endothelial damage or activation in an individual comprising:
- obtaining a fluid sample from the individual,
- detecting the level of a fragment of ECSM4 in the sample,
- comparing the level of the fragment of ECSM4 in the sample to the level of the fragment of ECSM4 in a sample from an individual who does not have endothelial damage or activation, or to the level of the fragment of ECSM4 in an individual who does have endothelial damage or activation, and
- determining whether the level of the fragment of ECSM4 in the individual indicates endothelial damage or activation,
- wherein the level of the fragment of ECSM4 is detected using an antibody that selectively binds to a polypeptide having at least 90% identity to the amino acid sequence of SEQ ID NO:37 or SEQ ID NO:24.
2 more elements
A method of detecting a tumour, tumour neovasculature, cardiac disease, endometriosis, or atherosclerosis in an individual comprising:
- obtaining a fluid sample from the individual,
- detecting the level of a fragment of ECSM4 in the sample,
- comparing the level of the fragment of ECSM4 in the sample to the level of the fragment of ECSM4 in a sample from an individual who does not have a tumour, tumour neovasculature, cardiac disease, endometriosis, or atherosclerosis, or to the level of the fragment of ECSM4 in an individual who does have a tumour, tumour neovasculature, cardiac disease, endometriosis, or atherosclerosis, and
- determining whether the level of the fragment of ECSM4 indicates a tumour, tumour neovasculature, cardiac disease, endometriosis, or atherosclerosis in the individual,
- wherein the level of the fragment of ECSM4 is detected using an antibody that selectively binds to a polypeptide having at least 90% identity to the amino acid sequence of SEQ ID NO:37 or SEQ ID NO:24.
2 more elements
Dependencies are inferred from the claim text.