Therapeutic molecules
AssigneeThe Walter and Eliza Hall Institute of Medical Research
InventorsSuzanne Cory, Jerry Adams, David C. S. Huang, Liam O'Connor, Andreas Strasser, Hamsa Puthalakath, Lorraine O'Reilly
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Abstract
The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
Claims18
A method for detecting a Bim molecule encoded by the human Bim gene on human chromosome 2 at bands 2q 12-2q 13 or the mouse Bim gene on chromosome 2 at bands F3-G in a biological sample comprising:
- providing a biological sample from a subject that contains a Bim molecule;
- contacting said biological sample that contains said Bim molecule with an antibody specific for SEQ ID NO:
- 10 under conditions sufficient to bind said Bim molecule;
- and
- detecting the presence or absence of a complex comprising said a Bim molecule and said antibody.
A method for detecting a Bim molecule that is at least 89% identical to the human BimEL sequence of SEQ. ID. No. 10 in a biological sample comprising:
- providing a biological sample from a subject that contains said Bim molecule;
- contacting said biological sample that contains said Bim molecule with an antibody specific for SEQ ID NO:
- 10 under conditions sufficient to bind said Bim molecule;
- and
- detecting the presence or absence of a complex comprising said Bim molecule and said antibody.
A method for detecting a Bim molecule that is at least 85% identical to the human BimL sequence of SEQ. ID. No. 8 in a biological sample comprising:
- providing a biological sample from a subject that contains said Bim molecule;
- contacting said biological sample that contains said Bim molecule with an antibody specific for SEQ ID NO:
- 8 under conditions sufficient to bind said Bim molecule;
- and
- detecting the presence or absence of a complex comprising said Bim molecule and said antibody.
Dependencies are inferred from the claim text.