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US 7,582,425 B2Granted
Atlastin
AssigneeThe Regents of the University of Michigan
InventorsJohn K. Fink, Xinping Zhao
Life of this patent
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Abstract
The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment of these disabling diseases.
Claims7
A method of detecting a mutation in an atlastin gene in a nucleic acid sample comprising:
- a) analyzing a nucleic acid sample containing the atlastin gene to determine the nucleotide sequence of the atlastin gene, wherein said nucleic acid sample is obtained from a human subject;
- and
- b) comparing the nucleotide sequence of the atlastin gene in the sample with the nucleotide sequence of a control sample containing the wild type atlastin gene comprising SEQ ID NO:1, wherein a difference in the nucleotide sequence of the sample atlastin gene sequence and SEQ ID NO:1 is indicative of a mutation in the atlastin gene contained in the sample.
Dependencies are inferred from the claim text.