Accessory cholera enterotoxin and analogs thereof as activators of calcium dependent chloride channel
AssigneeUniversity of Maryland, Baltimore
InventorMichele Trucksis
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Abstract
Vibrio cholerae accessory cholera enterotoxin (ACE) activates a calcium dependent chloride channel. Ace and Ace analogs can be administered to patients to treat diseases involving defects in chloride secretion by the cystitis fibrosis transmembrane receptor (CFTR). Cystic fibrosis, Dent's disease, X-linked nephrolithiasis, X-linked recessive hypophosphatemic rickets, autosomal dominant myotonia congenita and autosomal recessive general myotonia can be treated by the administration of Ace or an Ace analog. For cystic fibrosis, administration of Ace or an Ace analog increases chloride secretion in the lungs which increases the amount of airway surface water in the lumen of the lungs.
Claims9
A method for treating a disease characterized by a defect in ion transport, wherein said disease is selected from the group consisting of cystic fibrosis, Dent's disease, X-linked nephrolithiasis, X-linked recessive hypophosphatemic rickets, autosomal dominant myotonia congenita, and autosomal recessive general myotonia, wherein said method comprises administering a therapeutically effective amount of a polypeptide consisting of the amino acid sequence of SEQ ID NO:5, to an animal having said disease, and wherein said method results in an increase in the amount of airway surface water in the lungs of said animal.
Dependencies are inferred from the claim text.