LbL-coated medical device and method for making the same

A method for producing a medical device having a biocompatible LbL coating, comprising the steps of:

• (a) contacting said medical device with a solution of a charged polymeric material to form a layer of the charged polymeric material,
• (b) optionally rinsing said medical device by contacting said medical device with a rinsing solution;
• (c) contacting said medical device with a solution of a non-charged polymeric material to form a layer of the non-charged material on top of the layer of the charged polymeric material, wherein the non-charged polymeric material is capable of being non-covalently bond to the charged polymeric material in said biocompatible LbL coating;
• and
• (d) optionally rinsing said medical device by contacting said medical device with the rinsing solution,
• wherein said charged polymeric material is a first polyanionic polymer or a mixture of two or more polyanionic polymers, and wherein said non-charged material is a homopolymer of a vinyl lactam of formula (I), a copolymer of at least one vinyl lactam of formula (I) in the presence or in the absence of one or more hydrophilic vinylic comonomers, or mixture thereof
• wherein
• R is an alkylene di-radical having from 2 to 8 carbon atoms,
• R1 is hydrogen, C1-C10 alkyl, aryl having up to 10 carbon atoms, aralkyl or alkaryl having up to 14 carbon atoms, and
• R2 is hydrogen or C1-C10 alkyl.