US 7,582,311 B1 · Injection vehicle for polymer-based formulations

Abstract

The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of manufacture, and kits. Other aspects of the invention included methods for producing and administering pharmaceutical formulations. The injection vehicles of the invention are superior to conventional injection vehicles in that they include a pseudoplastic composition that improves injectability, which facilitates delivery of the desired dose. The injection vehicles of the invention also allow the use of smaller-bore needles than are usually necessary to inject polymer-based formulations, reducing the pain associated with injection of such formulations.

Claims44

Dependent claims

A method for administering a biologically active agent, the method comprising:

injecting to an animal a formulation comprising:
(a) an injection vehicle comprising hyaluronic acid or sodium hyaluronate dissolved in a physiological buffer at a concentration of about 0.01 to about 3 percent weight per volume;
and
(b) particles comprising:
(i) a first component that is the biologically active agent;
and
(ii) a second component that is a biocompatible polymeric matrix,
wherein the concentration of the particles is about 100 mg/mL to about 500 mg/mL of the formulation, and further wherein the hyaluronic acid or sodium hyaluronate is at a concentration sufficient to inject the formulation through a 23-gauge or smaller bore needle.

5 more elements

Dependencies are inferred from the claim text.

Injection vehicle for polymer-based formulations

Life of this patent

Injection vehicle for polymer-based formulations

Life of this patent

Abstract

Claims44