Cohesive demineralized bone compositions
AssigneeEtex Corporation
InventorsAron D. Rosenberg, Laurent Gilles de Pelichy
Life of this patent
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Abstract
Demineralized bone matrix fibers and a demineralized bone matrix composition are provided. The demineralized bone matrix fibers have an average fiber length in the range from about 250 μm to about 2 mm and an aspect ratio of greater than about 4. The demineralized bone matrix composition includes demineralized bone matrix fibers and a biocompatible liquid in an amount to produce a coherent, formable mass. The formable mass retains its cohesiveness when immersed in a liquid. Methods for making the demineralized bone matrix fibers and composition are also provided.
Claims39
A demineralized bone matrix composition comprising:
- fibers of demineralized bone matrix consisting of fiber lengths between 250 μm to 2 mm and an aspect ratio of greater than about 4;
- and
- a biocompatible liquid in an amount to produce a coherent, formable mass.
A demineralized bone matrix composition comprising:
- (a) a dry component comprising fibers of demineralized bone matrix consisting of fiber lengths between 250 μm to 2 mm and an aspect ratio of greater than about 4, wherein said demineralized bone matrix fibers are present in an amount greater than 40 wt % of said dry component, and
- (b) a biocompatible liquid in an amount to produce a coherent formable mass.
A demineralized bone matrix fiber composition, comprising:
- a collection of fibers of demineralized bone matrix of which at least 25 wt % between 250 μm to 2 mm and an aspect ratio of greater than about 4.
A preformed demineralized bone matrix article having a predetermined shape, said article comprising:
- fibers of demineralized bone matrix having consisting of fiber lengths between 250 μm to 2 mm and an aspect ratio of greater than about 4;
- and
- a biocompatible liquid in an amount to produce a coherent, formable mass.
A method for making a demineralized bone matrix composition, comprising:
- combining fibers of demineralized bone matrix, having consisting of fiber lengths between 250 μm to 2 mm and an aspect ratio of greater than about 4, and an amount of a biocompatible liquid to produce a coherent, formable mass.
A method of making a preformed demineralized bone matrix article having a predetermined shape comprising:
- combining fibers of demineralized bone matrix having consisting of fiber lengths between 250 μm to 2 mm and an aspect ratio of greater than about 4, and an amount of a biocompatible liquid to produce a coherent, formable mass;
- forming the mass into a preformed article having the predetermined shape;
- and
- drying the preformed article.
Dependencies are inferred from the claim text.