Groups of Borrelia burgdorferi and Borrelia afzelii that cause Lyme Disease in humans
AssigneesThe Research Foundation of State University of New York, Brook Biotechnologies, Inc.
InventorsRaymond J. Dattwyler, Gerald Seinost, Daniel Dykhuizen, Benjamin J. Luft, Maria J. C. Gomes-Solecki
Life of this patent
Estimating the term…
Abstract
The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia burgdorferi OspC families A, B, I and K. In another embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia afzelii OspC families A and B.
Claims21
A method of immunizing an animal against Lyme disease, comprising administering a composition comprising at least two OspC polypeptides from Lyme Disease causing Borrelia wherein said composition comprises one or more OspC polypeptides from at least two Borrelia burgdorferi sensu stricto OspC families selected from the group consisting of:
- A, B, I and K, excepting the combination consisting of two OspC proteins wherein one OspC protein is from OspC family A and the second OspC protein is from OspC family I.
A method of detecting an immune response to Lyme Disease causing Borrelia in a host sample, comprising;
- a) contacting the host sample with a composition comprising OspC polypeptides from Lyme disease causing strains of Borrelia, such that anti-OspC antibodies, if present in said sample bind to said OspC polypeptides;
- wherein said composition comprises one or more OspC polypeptides from at least two Borrelia burgdorferi sensu stricto OspC families selected from the group consisting of:
- A, B, I and K, excepting the combination consisting of two OspC proteins wherein one OspC proteins is from family A and the second OspC protein is from family I, and
- b) detecting antibodies that have bound said OspC peptides;
- thereby detecting an immune response to Lyme disease causing Borrelia.
Dependencies are inferred from the claim text.