Modulation of gamma delta T cells to regulate airway hyperresponsiveness
AssigneeNational Jewish Health
InventorsErwin Gelfand, Willi K. Born, Michael F. Lahn, Arihiko Kanehiro
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Abstract
Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of γδ T cells in a patient. Also disclosed are methods for identifying compounds that regulate airway hyperresponsiveness by modulating γδ T cell action.
Claims19
A method to reduce airway hyperresponsiveness in a mammal, comprising administering to a mammal a phosphoantigen that activates γδ T cells, wherein the activation of said γδ T cells reduces airway hyperresponsiveness in said mammal and said mammal has, or is at risk of developing, a respiratory condition associated with airway hyperresponsiveness.
A method to reduce airway hyperresponsiveness in a mammal, comprising administering to a mammal a composition consisting essentially of a phosphoantigen that activates γδ T cells, wherein the activation of said γδ T cells reduces airway hyperresponsiveness in said mammal and said mammal has, or is at risk of developing, a respiratory condition associated with airway hyperresponsiveness.
Dependencies are inferred from the claim text.